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Venetoclax is a high-potency active pharmaceutical ingredient (API) primarily used in the treatment of certain types of blood cancers, such as chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). It works as a selective BCL-2 inhibitor, promoting apoptosis in cancer cells by blocking the anti-apoptotic protein BCL-2, which is often overexpressed in these malignancies. This mechanism helps to restore the natural process of cell death, thereby reducing the number of cancerous cells in the body.
| Chemical formula | C22H25ClN6O2 |
| Molecular weight | 437.93 g/mol |
| Purity | Typically ≥ 98% |
| Form | Powder or crystalline form |
| Solubility | Soluble in DMSO, slightly soluble in water |
When selecting Venetoclax, buyers should consider the required purity levels, which typically should be 98% or higher for therapeutic applications. It's also important to specify the form of the API, whether in powder or crystalline form, and to inquire about the available quantities. Additionally, certifications such as Good Manufacturing Practice (GMP) compliance may be relevant depending on the intended use in drug formulation or clinical trials.
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Venetoclax is primarily used in the treatment of chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL).
Venetoclax works by inhibiting the BCL-2 protein, which helps cancer cells survive, thus promoting cell death in these malignant cells.
The typical purity of Venetoclax is 98% or higher.
Venetoclax is available in powder or crystalline form.
Venetoclax is slightly soluble in water but more soluble in DMSO.
Venetoclax is used in oncology, pharmaceutical manufacturing, clinical research, and biotechnology.