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Low Substituted Hydroxypropyl Cellulose (L-HPC) is a cellulose derivative commonly used as a pharmaceutical excipient. It is produced by the etherification of cellulose with hydroxypropyl groups, resulting in a compound that is soluble in water and exhibits excellent swelling properties. L-HPC is primarily utilized as a disintegrant in tablet formulations, aiding in the rapid breakdown of tablets upon ingestion.
| Chemical structure | Cellulose derivative with hydroxypropyl substitutions |
| Appearance | White to off-white powder |
| Solubility | Soluble in water and alcohol |
| pH range | 6.0 to 8.0 |
| Moisture content | Typically less than 5% |
| Viscosity | Varies based on substitution degree, typically low to medium |
When selecting Low Substituted Hydroxypropyl Cellulose, consider the degree of substitution, as this can affect its disintegration properties. Buyers should specify the desired viscosity and particle size for their applications, as well as any relevant regulatory requirements or certifications. Quantities may vary based on production needs, so it's advisable to request quotes for both bulk and smaller quantities.
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It is primarily used as a disintegrant in tablet formulations.
Yes, it is widely used and considered safe in pharmaceutical applications.
It promotes the rapid breakup of tablets upon contact with fluids, enhancing bioavailability.
Yes, it is also used as a food additive and in nutraceuticals.
It should be stored in a cool, dry place away from direct sunlight.
It is generally considered hypoallergenic, but always check specific formulations.