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(S)-BINOL, or (S)-1,1'-bi-2-naphthol, is a chiral compound widely used as an intermediate in the synthesis of various pharmaceuticals. It is composed of two naphthalene rings connected by a single bond, with a specific stereochemistry that imparts unique properties to the compound. This enantiomer-specific intermediate plays a crucial role in asymmetric synthesis, allowing for the production of enantiomerically pure compounds essential in drug development.
| Chemical formula | C20H16O2 |
| Molecular weight | 288.34 g/mol |
| Purity | Typically > 98% |
| Melting point | Approximately 180-185 ┬░C |
| Solubility | Soluble in organic solvents such as ethanol and acetone |
When selecting (S)-BINOL, buyers should consider the required purity levels and any specific grades needed for their applications. It's essential to specify the desired quantity and any necessary certifications, such as GMP compliance, if applicable. Additionally, buyers may want to inquire about the supplier's ability to provide documentation for quality control and testing results.
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It is primarily used as a chiral intermediate in the synthesis of pharmaceuticals.
It is typically synthesized through various organic reactions involving naphthalene derivatives.
Purity levels are usually above 98%.
Yes, it is often used as a chiral catalyst in asymmetric synthesis.
It should be stored in a cool, dry place away from light.
Standard safety precautions should be followed, including the use of gloves and goggles.